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A population-based epidemiological survey of human parvovirus B19 infection: a project of the Kyushu and Okinawa Population Study (KOPS)

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Abstract

Human parvovirus B19 infection occurs by droplet nuclei through the respiratory tract and causes a wide range of diseases. It can be transmitted through blood transfusion from asymptomatic blood donors. This study was done to investigate the parvovirus B19 infection rate of a group of healthy Japanese residents. Of 2,081 blood samples tested, 15 (0.72 %) were positive for parvovirus B19 IgM, 1,412 (67.9 %) for B19 virus IgG, and 4 (0.2 %) for parvovirus B19 DNA. About half of all women of childbearing age were susceptible to parvovirus B19 infection. No relationship was found between the frequency of symptoms and the prevalence of parvovirus B19 IgG and IgM, suggesting that there are asymptomatic carriers in the healthy Japanese population. There is a risk of parvovirus B19 infection by blood transfusion from asymptomatic donors and that pregnant women are at high risk for parvovirus B19 infection.

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Acknowledgments

We are grateful to Drs. Mosaburo Kainuma, Hiroaki Taniai, Eiichi Ogawa, Hachiro Ohnishi, Haru Mukae, Mami Unno, Tsunehisa Koga, Kunimitsu Eiraku, Hiroaki Ikezaki, Fujiko Mitsumoto, and Koji Takayama for collecting data and checking the questionnaires from the participants. We are also grateful to Mr. Yoshitake Etoh for his excellent PCR lab work on the parvovirus B19 DNA, and to Miss Setsuko Nagata and the nurses of Ishigaki City, Okinawa Prefecture, for assisting with this study.

This work was supported in part by the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study), Scientific Support Program for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas (no. 221 S001), and Grant-in-Aid for Comprehensive Research of the 21st Century COE Program from the Ministry of Education, Culture, Sports Science and Technology in Japan.

Competing interest

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Department of Environmental Medicine and Infectious Diseases, Kyushu University, 3-1-1, Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan

    Takeshi Ihara & Takeo Hayashi

  2. Department of General Internal Medicine, Kyushu University Hospital, 3-1-1, Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan

    Norihiro Furusyo, Kazuhiro Toyoda, Masayuki Murata & Jun Hayashi

Authors
  1. Takeshi Ihara
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  2. Norihiro Furusyo
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  3. Takeo Hayashi
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  4. Kazuhiro Toyoda
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  5. Masayuki Murata
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  6. Jun Hayashi
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Correspondence to Jun Hayashi.

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Ihara, T., Furusyo, N., Hayashi, T. et al. A population-based epidemiological survey of human parvovirus B19 infection: a project of the Kyushu and Okinawa Population Study (KOPS). Arch Virol 158, 2465–2472 (2013). https://doi.org/10.1007/s00705-013-1746-z

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  • DOI: https://doi.org/10.1007/s00705-013-1746-z

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