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Myelodysplasia presenting as thoracic spinal epidural extramedullary hematopoiesis: a rare treatable cause of spinal cord myelopathy

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Abstract

We present clinical, magnetic resonance imaging, and pathological findings of a 61-year-old patient with an otherwise asymptomatic myelodysplastic syndrome presenting with progressive paraparesis from epidural thoracic spinal extramedullary hematopoiesis. Surgical spinal cord decompression resulted in complete clinical remission.

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References

  1. McKinley WO, Tewksbury MA, Godbout CJ. Comparison of medical complications following nontraumatic and traumatic spinal cord injury. J Spinal Cord Med. 2002;25:88–93.

    PubMed  Google Scholar 

  2. Catz A, Goldin D, Fishel B, Ronen J, Bluvshtein V, Gelernter I. Recovery of neurologic function following nontraumatic spinal cord lesions in Israel. Spine (Philadelphia Pa 1976) 2004;29:2278–82.; discussion 2283.

  3. Koch CA, Li CY, Mesa RA, Tefferi A. Nonhepatosplenic extramedullary hematopoiesis: associated diseases, pathology, clinical course, and treatment. Mayo Clin Proc. 2003;78:1223–33.

    Article  PubMed  Google Scholar 

  4. Amirjamshidi A, Abbassioun K, Ketabchi SE. Spinal extradural haematopoiesis in adolescents with thalassemia. Child Nerv Syst. 1991;7:223–5.

    Article  CAS  Google Scholar 

  5. Bennet JM, Catousky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, et al. Proposal for the classification of the myelodysplastic syndromes. Br J Haematol. 1982;51:189–99.

    Google Scholar 

  6. Guermazi A, Miaux Y, Chiras J. Imaging of spinal cord compression due to thoracic extramedullary haematopiesis in myelofibrosis. Neuroradiology. 1997;39:733–6.

    Article  PubMed  CAS  Google Scholar 

  7. Horwood E, Dowson H, Gupta R, Kaczmarski R, Williamson M. Myelofibrosis presenting as spinal cord compression. J Clin Pathol. 2003;56:154–6.

    Article  PubMed  CAS  Google Scholar 

  8. Dibbern D, Loevner A, Lieberman AP, Salhany K, Freese A, Marcotte PJ. MR of thoracic cord compression caused by epidural extramedullary hematopoiesis in myelodysplastic syndrome. AJNR Am J Neuroradiol. 1997;18:363–6.

    PubMed  Google Scholar 

  9. Savini P, Lanzi A, Marano G, Carli Moretti C, Poletti G, Musardo G, et al. Paraparesis induced by extramedullary haematopoiesis. World J Radiol. 2011;3:82–4.

    Article  PubMed  Google Scholar 

  10. Rajiah P, Hayashi R, Bauer TW, Sundaram T. Extramedullary hematopoiesis in unusual locations in hematologically compromised and noncompromised patients. Skeletal Radiol. 2011;40:947–53.

    Article  PubMed  Google Scholar 

  11. Gatto I, Terrana V, Biondi L. Compressione sul midollo spinale da proliferazione di midollo osseo nello spazio epidurale in soggetto affetto da Malattia di Cooley splenectomizzato. Haematologica. 1954;38:61–75.

    PubMed  CAS  Google Scholar 

  12. Kafmann T, Coleman M, Giardina P, Nisce LZ. The role of radiation therapy in management of hematopoietic neurologic complications in talassemia. Acta Haematol. 1991;85:156–9.

    Article  Google Scholar 

  13. Cross JN, Morgan OS, Gibbs WN, Cheruvanky I. Spinal cord compression in thalassemia. J Neurol Neurosurg Psychiatry. 1997;40:1120–2.

    Article  Google Scholar 

  14. Shin KH, Sharma S, Gregoritch SJ, Lifeso RM, Bettigole R, Yoon SS. Combined radiotherapeutic and surgical management of a spinal cord compression by extramedullary hematopoisis in a patient with hemoglobin betathalassemia. Acta Hematol. 1994;91:154–7.

    Article  CAS  Google Scholar 

  15. Konstantopoulos K, Vagiopoulos G, Kantouni R. A case of spinal cord compression by extramedullary hematopoisis in a thalassamic patient: a putative role for hydroxyurea? Haematologica. 1992;77:352–4.

    PubMed  CAS  Google Scholar 

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The authors declare that they have no conflicts of interest.

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Correspondence to Alfonso Cerase.

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Monti, L., Romano, D.G., Gozzetti, A. et al. Myelodysplasia presenting as thoracic spinal epidural extramedullary hematopoiesis: a rare treatable cause of spinal cord myelopathy. Skeletal Radiol 41, 611–614 (2012). https://doi.org/10.1007/s00256-011-1268-2

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  • DOI: https://doi.org/10.1007/s00256-011-1268-2

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