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Serum angiotensin converting enzyme in pulmonary disease

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Abstract

Synthetic acylated tripeptides, which may or may not be radiolabelled, are generally used as substrates for measuring serum angiotensin converting enzyme (SACE) activity. The capillary endothelial cells are the major source of SACE in normals and certain diseased states, however Gaucher’s cells in Gaucher’s disease and epithelioid cells in granulomatous disorders, including sarcoidosis, are the major source of enzyme in these disorders. SACE is generally elevated in active sarcoidosis and is normal when the disease is dormant or resolved. Sequential measurement of SACE are helpful in monitoring activity of sarcoidosis, both off and on corticosteroids. SACE may also be elevated in certain non-granulomatous pulmonary and systemic diseases.

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Authors and Affiliations

  1. Pulmonary Division (151m), Veterans Administration Medical Center, 50 Irving St., N.W., 20422, Washington, D.C., USA

    P. K. Rohatgi

  2. Division of Pulmonary Diseases and Allergy, George Washington University Medical Center, Washington, D.C., USA

    P. K. Rohatgi

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Rohatgi, P.K. Serum angiotensin converting enzyme in pulmonary disease. Lung 160, 287–301 (1982). https://doi.org/10.1007/BF02719304

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