Table 1

Cases of bilateral breast metastasis of serous ovarian carcinoma in the literature

Author (year)AgeStagePresentationLymphadenopathyHistologyTreatmentSerumImmuno-histochemistryOutcome (interval*)
Krishnan (1980)160N/AEdema, Erythema, Induration, TendernessNonePapillary serous, psammoma bodiesChemotherapy, radiationN/AN/ADeath (6 months)
Hughes (1983)248N/AMassAxillaryPapillary adenocarcinomaMastectomyN/AN/ADeath (5 months)
Wadhwa (1999)345IVInduration, Peau d’orangeAxillary, supraclavicularPapillary serous, focal calcifications, psammoma bodiesChemotherapy, mastectomy, radiationCA-125N/AProgression (25 months)
Ozgüroğlu (1999)455IIIcEdema, Erythema, IndurationSupraclavicularPapillary adenocarcinomaN/ACA-125N/ADeath (3 months)
Özsaran (2000)541N/AEdema, Mass, Nipple retraction, Peau d’orangeAxillaryPapillary serous, microcalcificationsChemotherapyCA-125p53 (+)Death (N/A)
Oksüzoğlu (2001)6N/AIIIcN/AAxillaryPapillary cyst-adenocarcinomaChemotherapyCA-125N/APartial response (18 months)
Kayikçioğlu (2001)733IIIcErythema, Induration, TendernessAxillaryPapillary serousChemotherapy, hormone therapyCA-125OC125 (+)GCDFP (−)ER (−)Death (18 months)
Gökaslan (2005)868N/AMassAxillaryPapillary serous cystadenocarcinomaChemotherapyN/ACA-125 (+), CA15-3 (+)N/A (N/A)
Fulciniti (2008)949IIIMassNoneSerous carcinoma, microcalcifications, psammoma bodiesChemotherapyN/ACA-125 (+)WT-1 (+)N/A (N/A)
Khalifeh (2009)1056IVErythemaAxillarySerous carcinoma, calcifications, psammoma bodiesChemotherapy, hormone therapy, mastectomy, radiationCA-125, CA27.29ER (+),PR (−),WT-1 (+), GCDFP (−)Good response (16 months)
  • *Interval: since breast involvement.

  • CA-125, cancer antigen 125; CA 15-3, cancer antigen 15-3; ER, estrogen receptor; GCDFP, gross cystic disease fluid protein; OC-125, monoclonal antibody for CA-125 antigen; WT-1, Wilms’ tumour-1 antigen.