Documented cases of rituximab associated inflammatory vaginitis
| Patient age and (no of patients) | Initial condition treated with rituximab | Additional immunosuppressive drugs prior to developing vaginitis | Study |
| Age less than 50 years (5) Age 50 and older (3) | ANCA associated vasculitis | Not described | Murphy et al9 |
| Age less than 50 years (8) Age 50 and older (8) | 11 cases had ANCA associated vasculitis 1 case had Lupus nephritis 4 cases had another diagnosis | 15 cases received cyclophosphamide as part of their induction protocol | Yockey et al10 |
| Age less than 50 (1) | Multiple sclerosis | No | Our patient |
The clinical features associated with inflammatory vaginitis include vaginal discharge (often copious), vaginal pain, irritation and dyspareunia, vaginal pH>5, absence of lactobacilli and high numbers of white blood cells in vaginal fluid.
ANCA, Anti-neutrophil cytoplasm antibodies; MS, Multiple sclerosis; PG, Pyoderma gangrenosum; RRMS, Relapsing-remitting multiple sclerosis.