Table 1

Pertinent laboratory results by clinical course progression, including prenatal visit and first and second hospital admissions for COVID-19 positive primigravida who died on PPD 22, Chicago, Illinois, USA

VariableReference
range
Laboratory results*
First admission†Second admission‡
Prenatal visitPPD 0–2PPD 11–14PPD 15–18PPD 19–22
Prenatal laboratory tests
RPR test for syphilisNegative
Rubella IgGImmune
Blood group and Rh factorA+A+
Ab screenNegativeNegative
HIV 1/2 Ab and AgNon-reactiveNon-reactive
Microbiology/immunology laboratory tests
SARS-CoV-2 by RT-PCRPositive
Influenza ANegative
Influenza BNegative
QuantiFERON-TB GoldNegative
HBS AntigenNegative
Antihepatitis C virusNegative
Legionella antigenNegative
Inflammatory markers
CRP (mg/L)<8.145.0218.8–239.8159.9
ESR (mm)0–2032
Procalcitonin (ng/mL)<0.060.55
Ferritin (ng/mL)11–241565–1256504
Serum IL-6 (pg/mL)<5.080.1
D-dimer (ng/mL)<5007341–62 23665456311–18 416
Serum electrolytes
Na (mmol/L)133–144127–132137–142139–147138–143
K (mmol/L)3.5–5.13.0–3.93.4–4.62.3–5.33.7–5.3
Cl (mmol/L)98–10898–101105–112108–113104–120
CO (mmol/L)20–3220–2211–1922–2611–21
Ca (mg/dL)8.6–10.37.3–8.37.4–7.97.4–8.37.7–8.4
Glucose (mg/dL)70–10074–93109–16284–12239–126
Total protein (mg/dL)6.4–8.35.1–5.85.0–6.15.3–5.85.6–6.1
Mg (mg/dL)1.6–2.61.31.9–2.11.9–2.31.6–2.1
P (mg/dL)2.5–4.76.61.3–64.6–6.5
Blood cell counts
WCC (x109/L)4–115–8.920.9–38.314.6–20.713.3–39.2
Neutrophil (%)7276.3–83.572–9071–8135–82
Lymphocyte (%)209.1–14.72–71–86–24
Monocyte (%)7.1–12.81–73–136–14
Meta myelocytes (%)1–51–62–10
Myelocyte (%)1–41–52–7
Eosinophil (%)011
Basophil (%)0.1–0.51
RCC (x1012/L)3.8–5.42.96–4.613.46–4.433.36–3.573.28–3.54
Hb (g/L)115–15576–12091–11489–9786–93
Hct (%)34–46.523.2–36.428.9–3827.7–29.927.7–32.0
Platelet count (k/mm cu)150–450126–16081–188151–254255–329
Band (%)3–153–102–18
Nucleated RCC (%)<14–231–91–13
Coagulation Parameters
PT (seconds)9.7–13.112.420.8–20.9
INR0.8–1.21.21.8
aPTT (seconds)26.8–36.029.2–81.952.8–110.346.9–177.5
Liver function tests
AST (U/L)10–4026–2733–1856173–40994–1084
ALT (U/L)7–3517–2123–1103269–806107–284
Albumin (mg/dL)3.5–5.72.7–3.21.7–2.51.8–2.11.5–1.8
Total bilirubin (mg/dL)0.0–1.40.84.3–6.56.2–7.73.6–5.7
Direct bilirubin (mg/dL)0.0–0.33.5–4.34.2–4.2
ALP (U/L)30–11067–9566–8875–8089–137
TG (mg/dL)<150526426320–482
Renal Function Tests
BUN (mg/dL)7–254–815–5842–6141–64
Creatinine (mg/dL)0.5–1.40.61–0.651.01–2.751.42–2.201.53–4.25
Estimated GFR (mL/min/1.73m2)t>89
>6023–7730–5114–46
BUN/creatinine6.0–20.06.2–13.114.944.0–61.0
Anion gap (mmol/L)6.2–14.78.0–10.010.0–20.05.0–13.010.0–16.0
Cardiac function markers
BNP (pg/mL)1–100898–10351391
Troponin (ng/mL)0.00–0.020.07–0.240.03–0.060.06
CK (u/L)35–20070–101150
LDH (u/L)108–2121751–2737
Lactic acid (mm/L)
Arterial0.4–1.32.3–3.1
Venous0.0–2.51.27.6
Blood gas parameters
pH7.36–7.467.17–7.307.38–7.496.86–7.44
pCO2 (mm Hg)32–4632–4838–4231–72
pO2 (mm Hg)83–10836–20360–32037–124
hCO3 (mm/L)21–2914–2222–2912–23
BE, calculated (mmol/L)
(−8) – (−12)(-2)–5(−1) – (−21)
Carboxyhaemoglobin (%)0.0–2.01.3–1.7
Methaemoglobin (%)0.0–1.51.3–1.5
Ca, ionised (mm/L)1.15–1.301.06
Ca, ionised pH corrected (mm/L)1.15–1.300.98
  • *Results provided as a 3-day range for simplicity of presentation.

  • †First admission: prenatal visit, 6 September 2019; PPD 0–2, 1–3 April 2020.

  • ‡Second admission: PPD 11–14, 12–15 April 2020; PPD 15–18, 16–19 April 2020; PPD 19–22, 20–23 April 2020; PPD 11–22, 12–23 April 2020.

  • Ab, antibody; ALP, alkaline phosphatase; ALT, alanine aminotransferase; aPTT, activated partial thromboplastin time; AST, aspartate aminotransferase; BE, base excess; BHCG, beta-human chorionic gonadotropin; BNP, brain natriuretic peptide; BUN, blood urea nitrogen; Ca, calcium; CK, creatine kinase; Cl, chloride; CO, carbon monoxide; CRP, C reactive protein; ESR, erythrocyte sedimentation rate; GFR, glomerular filtration rate; Hb, haemoglobin; HBS, hepatitis B surface antigen; hCO3, bicarbonate; hct, haematocrit; IL-6, interleukin 6; INR, international normalised ratio; K, potassium; LDH, lactate dehydrogenase; Mg, magnesium; Na, sodium; NP, nasopharyngeal; pCO2, partial pressure of carbon dioxide; pO2, partial pressure of oxygen; PPD, postpartum day; PT, prothrombin time; RCC, red cell count; Rh, Rhesus; RPR, rapid plasma reagin; TB, tuberculosis; TG, triglyceride; WCC, white cell count.