Table 1

Review of case reports with nivolumab-related IAD

Case	Age sex	Primary disease	Time to onset		Initial symptoms	Ref.
Case	Age sex	Primary disease	During treatment (courses)	After cessation (months)	Initial symptoms	Ref.
1	54/M	Lung cancer	8		Fatigue, anorexia, nausea, body pain	15
2	64/M	Lung cancer	7		Fatigue, anorexia, nausea, body pain	15
3	57/M	Lung cancer	6		Fatigue, anorexia, nausea, body pain	15
4	76/F	Melanoma	9		Fatigue, anorexia, nausea, body pain	15
5	70/M	Urothelial cancer	9		Fatigue, anorexia, nausea	16
6	50 s/M	Head and neck cancer	8		Fatigue, difficulty walking	17
7	69/M	Head and neck cancer	8		Fatigue, anorexia, nausea	18
8	73/M	Head and neck cancer	10		Fatigue, anorexia, arthralgia	18
9	69/F	Lung cancer		4	Fatigue, anorexia	19
10	52/F	Breast cancer		1	Fatigue	20
11	72/F	Melanoma		4	Fatigue, anorexia	21
12	79/M	Melanoma	20		Anorexia, nausea, difficulty walking	22
13	71/M	Renal cancer	14		Fatigue, anorexia, impaired consciousness	23
14	66/M	Renal cancer	8		Anorexia, exertional dyspnoea	24
15	73/M	Lung cancer		7	Fatigue, anorexia, weight loss	25
16	58/M	Melanoma		1	Fatigue, impaired consciousness	26
17	53/M	Melanoma	7		Fatigue, vomiting, myalgia	27
18	72/M	Melanoma	14		Fatigue, anorexia, vomiting	27
19	63/F	Lung cancer	17		Fatigue, anorexia, myalgia, difficulty walking	28
20	54/M	Renal cancer	12		Fatigue	29
21	74/F	Renal cancer	5		Fatigue, anorexia, nausea	30
22	75/M	Lung cancer	12		Fatigue, anorexia	31
23	60/M	Lung cancer	11		Fatigue, anorexia, exertional dyspnoea	32
24	72/M	Lung cancer	10		Fatigue, anorexia, vomiting	32
25	71/M	Lung cancer	10		Fatigue, anorexia, nausea	32
26	39/M	Melanoma	13		Fatigue, dizziness	33
27	55/M	Lung cancer	33		Fatigue, asthenia, depression, weight loss	34
28	76/F	Melanoma	9		Fatigue, anorexia, bradykinesia	35
29	81/F	Mesothelioma	8		Fatigue, abdominal pain	Present case

IAD, isolated adrenocorticotropic hormone deficiency.