Table 2

Managing patients with suspected or confirmed vaccine induced thrombotic thrombocytopaenia (VITT)

Laboratory testing by PF4 antibody assay (ELISA HIT assay)Do not exclude VITT based on a negative HIT screen from a rapid particle gel immunoassay
Commence therapeutic anticoagulation with non-heparin-based therapiesAvoid heparin, including heparin-based flushes. Fondaparinux can be used
Urgently treat with IVIGAvoid platelet transfusion
Consider giving corticosteroidsAvoid thrombopoietin receptor agonists
Report to regulatory health agenciesDo not give a second dose of any vaccine for SARS-CoV-2 until further data are available
  • HIT, heparin-induced thrombocytopaenia; IVIG, intravenous immunoglobulin; PF4, platelet factor 4.