Table 2

Serum autoimmune encephalopathy panel (performed by Mayo Clinic Laboratories)

Result nameResultReference value
Glutamic acid decarboxylase 65 antibody0.28 nmol/L≤0.02
Acetylcholine receptor Ganglionic Neuronal Ab0.00 nmol/L≤0.02
AMPA-R Ab CBANegativeNegative
Amphiphysin AbNegative<1:240
AGNA-1Negative<1:240
ANNA-1Negative<1:240
ANNA-2Negative<1:240
ANNA-3Negative<1:240
CASPR2-IgG CBANegativeNegative
CRMP-5-IgGNegative<1:240
DPPX Ab IFANegativeNegative
GABA-B-R Ab CBANegativeNegative
GFAP IFANegativeNegative
IgLON5 IFANegativeNegative
LGI1-IgG CBANegativeNegative
mGluR1 Ab IFANegativeNegative
NIF IFANegativeNegative
NMDA-R Ab CBANegativeNegative
N-type calcium channel Ab0.00 nmol/L≤0.03
P/Q-type calcium channel Ab0.00 nmol/L≤0.02
Purkinje cell cytoplasmic Ab type 1Negative<1:240
Purkinje cell cytoplasmic Ab type 2Negative<1:240
Purkinje cell cytoplasmic Ab type TrNegative<1:240
  • GAD65 Ab is consistent with predisposition to thyrogastric disorders, including thyroiditis, pernicious anaemia and type 1 diabetes, but has low specificity for autoimmune encephalopathy. GAD65 antibody values less than 2.00 nM have a lower positive predictive value for neurological autoimmunity than values of 20.0 nM and higher.

  • Ab, antibody; AGNA, antiglial nuclear antibody; AMPA-R Ab CBA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antibody cell-binding assay; ANNA, anti-neuronal nuclear antibody; CASPR2-IgG CBA, contactin-associated protein 2-immunoglobulin G cell-binding assay; CRMP-5-IgG, collapsin response-mediator protein-5- Immunoglobulin G; DPPX Ab IFA, dipeptidyl peptidase-like protein 6 antibody indirect fluorescent antibody; GABA-B-R Ab CBA, gamma-aminobutyric acid-B-receptor Antibody cell-binding assay; GFAP IFA, glial fibrillary acidic protein indirect fluorescent antibody; IgLON5 IFA, immunoglobulin-like cell adhesion molecule 5 Indirect fluorescent antibody; LGI1-IgG CBA, leucine rich glioma Inactivated 1- immunoglobulin G cell-binding assay; mGluR1 Ab IFA, metabotropic glutamate receptor 1 antibody indirect fluorescent antibody; NIF IFA, neuronal intermediate filament indirect fluorescent antibody; NMDA-R Ab CBA, N-methyl-D-aspartate receptor antibody cell-binding assay.