Table 3

Previous COVID-19 large-vessel occlusion strokes treatment courses

Author and year	Age	Sex	Brain Imaging				Vascular territory		Treatment for stroke			Timing of		Follow-up brain imaging
Author and year	Age	Sex	NCCT	CTA	MRI	CTP	Vascular territory	R/L	Intravenous tPA	EVT	Other therapy	Intravenous tPA	EVT	Follow-up brain imaging
Index case	67	M	✓	✓			ICA/vertebral\|	R/L			Aspirin/clopidogrel/atorvastatin	N/A	N/A	ACA territorial infarcts/MCA territorial infarcts
Mahboob et al,14 2020	58	F	✓	✓	✓		PICA	L	✓		Aspirin/clopidogrel\|		N/A	Focal brain oedema/mass effect\|
Cavallieri et al,21 2020	33	M	✓	✓			PICA/AICA/SCA	R/L			Hemicraniectomy/EVD	N/A	N/A	Obstructive hydrocephalus
Roy et al,22 2020	46	F	✓	✓			ACA/MCA\|	R			Aspirin/hemicraniectomy	N/A	N/A	Diffuse brain oedema mass effect/midline shift
Popov et al,34 2020	33	M	✓				MCA	L			Intravenous heparin	N/A	N/A
González-Pinto et al,35	36	F	✓	✓			ICA/MCA/ACA	L
Zhao et al,31 2020	60	M			✓
Duroi et al,36 2020	74	F	✓				MCA	L
Moshayedi et al,33 2020	80				✓		MCA	L						Haemorrhagic transformation
Co et al,16 2020	62	F	✓	✓			MCA	L	✓		Aspirin	3 hours 24 min		No ICH
Valderrama et al,37 2020	52	M	✓	✓		✓	ACA/MCA/ICA	L	✓	✓	Aspirin/atorvastatin			Petechial haemorrhages
Guillan et al,23 2020	67	M	✓		✓		MCA/PCA/SCA	R/L
Gunasekaran et al,38 2020	40	F	✓				MCA	R
Slootjes et al28 2020	74		✓	✓			ICA	R	✓	✓		3 hours 0 min	4 hours 30 min

ACA, anterior cerebral artery; AICA, anterior inferior cerebellar artery; CRP, C reactive protein; CTA, CT angiography; CTP, CT perfusion; EVD, External ventricular drain; EVT, endovascular thrombectomy; F, female; ICA, internal carotid artery; ICH, intracranial haemorrhage; IL, interleukin; L, left; LDH, lactate dehydrogenase; Lymph_abs, absolute lymphocyte count; M, male; MCA, middle cerebral artery; N/A, not applicable; NCCT, non-contrast CT; Neut_abs, absolute neutrophil count; PCA, posterior cerebral artery; PICA, posterior inferior cerebellar artery; PT, prothrombin time; PTT, partial thromboplastin time; R, right; SCA, superior cerebellar artery; tPA, tissue plasminogen activator; WBC, white blood cell.