Table 3

Modified Asbury Cornblath diagnostic criteria for GBS10 11

Required features
Progressive motor weakness of more than one limb.
Areflexia or decreased reflexes in weak limbs.
Supportive features
Progressive phase lasts up to 4 weeks.
Recovery beginning 2–4 weeks after progression ceases.
Autonomic dysfunction.
Relative symmetry.
Cranial nerve involvement, especially bilateral facial nerve weakness.
Mild sensory symptoms or signs.
Pain.
No fever at the onset.
Typical features of cerebrospinal fluid and nerve conduction studies.
The following features make the diagnosis of GBS doubtfulPossible alternative diagnosis
Sensory level.Cord compression/demyelination
Bowel and bladder dysfunction at onset.Cord compression
Severe and persistent bowel and bladder dysfunction.Cauda equina syndrome
Severe pulmonary dysfunction with little or no limb weakness at onset.Myasthenia gravis
Severe sensory signs with little or no weakness at onset.
Fever at onset.
CSF pleocytosis with a white cell count >50/µL.Meningitis
  • CSF, cerebrospinal fluid; GBS, Guillain-Barré syndrome.