Modified Asbury Cornblath diagnostic criteria for GBS10 11
Required features |
Progressive motor weakness of more than one limb. |
Areflexia or decreased reflexes in weak limbs. |
Supportive features |
Progressive phase lasts up to 4 weeks. |
Recovery beginning 2–4 weeks after progression ceases. |
Autonomic dysfunction. |
Relative symmetry. |
Cranial nerve involvement, especially bilateral facial nerve weakness. |
Mild sensory symptoms or signs. |
Pain. |
No fever at the onset. |
Typical features of cerebrospinal fluid and nerve conduction studies. |
The following features make the diagnosis of GBS doubtful | Possible alternative diagnosis |
Sensory level. | Cord compression/demyelination |
Bowel and bladder dysfunction at onset. | Cord compression |
Severe and persistent bowel and bladder dysfunction. | Cauda equina syndrome |
Severe pulmonary dysfunction with little or no limb weakness at onset. | Myasthenia gravis |
Severe sensory signs with little or no weakness at onset. | |
Fever at onset. | |
CSF pleocytosis with a white cell count >50/µL. | Meningitis |
CSF, cerebrospinal fluid; GBS, Guillain-Barré syndrome.