Table 1

Spectrum of mutations detected on targeted gene sequencing analysis of the bone marrow

GeneMutationNotesVAF
First evaluation
VAF
Second evaluation
JAK2V617FJanus kinase41%66%
IDH1R132CIsocitrate dehydrogenase 147%51%
SRFS2P95HSerine and arginine rich splicing factor 242%49%
ASXL1Frame-shiftAdditional sex combs like 1ND26%
  • The variant allele frequency (VAF) is indicated at each time point. The first evaluation was done ~2 years prior to the second evaluation (see figure 1).