Current published case reports on atypical tibial fractures associated with long-term bisphosphonate/antiresorptive use
| Case report | Age (in years)/sex | Diagnosis | Antiresorptive agent (duration) | Fracture site | Management |
|---|---|---|---|---|---|
| Bissonnette et al 14 | 77, F | Postmenopausal osteoporosis | Zoledronate (4 years) | Left tibial diaphyseal fracture | Intramedullary nail fixation |
| Breglia and Carter15 | 48, F | Rheumatoid arthritis, glucocorticoid-induced osteoporosis | Alendronate (12 years) | Left tibial diaphyseal fracture | Conservative |
| Odvina et al 16 | 54, F | Postmenopausal osteopenia | Risedronate (3 years) | Right pelvis and right tibia | Not specified |
| Imbuldeniya et al 17 | 76, F | Rheumatoid arthritis, osteomalacia, glucocorticoid-induced osteoporosis | Alendronate (3 years), pamidronate (6 years) | Bilateral proximal tibial metaphyseal fractures | Conservative |
| Schimpf et al 18 | 76, F | Rheumatoid arthritis, glucocorticoid-induced osteoporosis | Risedronate (5 years), strontium ranelate (2 years), zoledronate (4 years), denosumab (2 years) | Bilateral distal tibial metaphyseal fractures | Tibial plates+screws |