Table 1

Current published case reports on atypical tibial fractures associated with long-term bisphosphonate/antiresorptive use

Case reportAge (in years)/sexDiagnosisAntiresorptive agent (duration)Fracture siteManagement
Bissonnette et al 14 77, FPostmenopausal osteoporosisZoledronate (4 years)Left tibial diaphyseal fractureIntramedullary nail fixation
Breglia and Carter15 48, FRheumatoid arthritis, glucocorticoid-induced osteoporosisAlendronate (12 years)Left tibial diaphyseal fractureConservative
Odvina et al 16 54, FPostmenopausal osteopeniaRisedronate (3 years)Right pelvis and right tibiaNot specified
Imbuldeniya et al 17 76, FRheumatoid arthritis, osteomalacia, glucocorticoid-induced osteoporosisAlendronate (3 years), pamidronate (6 years)Bilateral proximal tibial metaphyseal fracturesConservative
Schimpf et al 18 76, FRheumatoid arthritis, glucocorticoid-induced osteoporosisRisedronate (5 years), strontium ranelate (2 years), zoledronate (4 years), denosumab (2 years)Bilateral distal tibial metaphyseal fracturesTibial plates+screws