Table 1

Tissue distribution of alpha chains of type IV chains of collagen

Type of alpha (IV) chainsDistribution in tissues
Alpha-1All tissues (Ubiquitous)
Alpha-2All tissues (Ubiquitous)
Alpha-3Kidney (GBM, distal TBM), Eye (Descemet membrane, Bruch membrane, anterior lens capsule), Lungs, Ear (cochlea)
Alpha-4Kidney (GBM, distal TBM), Eye (Descemet membrane, Bruch membrane, anterior lens capsule), Lungs, Ear (cochlea)
Alpha-5Kidney (GBM, distal TBM), Eye (Descemet membrane, Bruch membrane, anterior lens capsule), Lungs, Ear (cochlea)
Alpha-6Kidney (Distal TBM), Skin (epidermal basement membrane)
  • GBM, glomerular basement membrane; TBM, tubular basement membrane.