Syndrome severity and frequency scores before and after 1 year of immunotherapy and 2 weeks of antibiotic therapy
| Severity score | Frequency score | |||
| Before | After | Before | After | |
| POTS symptoms | ||||
| Orthostatic lightheadedness | 0 | |||
| Difficulty passing stool | 10 | 0 | 10 | 0 |
| Early satiety | 10 | 0 | 10 | 0 |
| Depression* | 10 | 0 | 10 | 0 |
| Problems sleeping | 10 | 0 | 10 | 0 |
| Swelling | 10 | 0 | 10 | 0 |
| Tinnitus | 10 | 0 | 10 | 0 |
| Visual sensitivity to light | 10 | 0 | 10 | 0 |
| Abdominal pain* | 10 | 1 | 10 | 1 |
| Dry mouth | 10 | 1 | 10 | 1 |
| Bloating* | 10 | 1 | 10 | 2 |
| Nocturnal urination (>1×) | 10 | 1 | 10 | 2 |
| Whole body pain | 10 | 1 | 10 | 2 |
| Frequent daytime urination | 10 | 1 | 10 | 4 |
| Leg pain | 10 | 2 | 10 | 4 |
| Extremities change colour | 10 | 3 | 10 | 5 |
| Sensitivity to heat and odour | 10 | 3 | 10 | 5 |
| Fainting | 10 | 0 | 9 | 0 |
| Fatigue* | 10 | 0 | 9 | 0 |
| Orthostatic tachycardia | 10 | 0 | 9 | 0 |
| Numbness and tingling | 10 | 3 | 9 | 4 |
| Facial flushing* | 10 | 0 | 8 | 0 |
| Vertigo | 9 | 0 | 8 | 0 |
| Hand pain | 8 | 0 | 10 | 0 |
| Headache* | 8 | 0 | 10 | 0 |
| Blurred vision | 8 | 0 | 8 | 0 |
| Joint pain | 8 | 0 | 8 | 0 |
| Muscular weakness | 8 | 0 | 8 | 0 |
| Shortness of breath* | 8 | 0 | 7 | 0 |
| Nausea | 7 | 0 | 8 | 0 |
| Dry eyes | 6 | 0 | 8 | 0 |
| Rashes* | 6 | 0 | 8 | 0 |
| Brain fog* | 4 | 0 | 8 | 0 |
| Total | 300 | 17 | 305 | 30 |
| MCAS symptoms | ||||
| Constipation (<3/week)* | 10 | 0 | 10 | 0 |
| Depression* | 10 | 0 | 10 | 0 |
| Insomnia* | 10 | 0 | 10 | 0 |
| Lightheaded (any position) | 10 | 0 | 10 | 0 |
| Chills | 10 | 1 | 10 | 0 |
| Abdominal pain* | 10 | 1 | 10 | 1 |
| Oedema* | 10 | 2 | 10 | 0 |
| Pressure-induced swelling | 10 | 2 | 10 | 5 |
| Heat intolerance | 10 | 3 | 10 | 5 |
| Fatigue* | 10 | 0 | 9 | 0 |
| Flushing* | 10 | 0 | 8 | 0 |
| Anxiety | 10 | 0 | 8 | 0 |
| Itching/hives | 10 | 0 | 7 | 0 |
| Sudden palpitations | 10 | 0 | 7 | 0 |
| Headaches* | 8 | 0 | 10 | 0 |
| Shortness of breath* | 8 | 0 | 7 | 0 |
| Environmental allergies | 7 | 1 | 8 | 1 |
| Nausea* | 7 | 2 | 6 | 0 |
| Panic attacks | 7 | 0 | 4 | 0 |
| Muscle pain* | 6 | 0 | 10 | 0 |
| Rashes* | 6 | 0 | 8 | 0 |
| Chest pain | 6 | 0 | 4 | 0 |
| Poor healing | 5 | 0 | 4 | 0 |
| Brain fog* | 4 | 0 | 8 | 0 |
| Total | 204 | 12 | 198 | 12 |
| SIBO symptoms | ||||
| Abdominal pain* | 10 | 1 | 10 | 1 |
| Foul and excessive flatus | 10 | 1 | 10 | 1 |
| Bloating* | 10 | 1 | 10 | 2 |
| Constipation (<3/week)* | 8 | 0 | 10 | 0 |
| Total | 38 | 3 | 40 | 4 |
*Symptoms that are shared by other syndromes.
MCAS, mast cell activation syndrome; POTS, postural orthostatic tachycardia syndrome; SIBO, small intestinal bacterial overgrowth.