Table 1

Summary of reported cases of HIV-related PCP managed with ECMO.

Age and sexNew or known HIVHIV viral load (copies/mL) on admission or diagnosisCD4 count (cells/mm3) on admission or diagnosisInitiation of ART (time following initiation of PCP treatment)Initial PCP treatmentTime to ECMO from initial admission (whole days)ECMO type
(VA or VV)
Duration of ECMO (whole days)Outcome
Our patient54
Female
New>1 075 70212During ECMO
(20 days)
TMP+SMX+FZ, then CL+PQ+CF9VV31Survived hospital discharge at 4 months
Gutermann et al3655
Male
New80 2359Post-ECMO
(4 weeks)
TMP+SMX
(CF started for invasive aspergillosis)
1.5VA4Survived hospital discharge at 2 months
Goodman et al3725
Male
New622 23436Pre-ECMO
(not recorded)
PM, then CL+PQ (allergic to TMP+SMX)18VV69Mortality during ECMO
Goodman et al3730
Female
New976 63113Post-ECMO
(16 days)
TMP+SMX3VV7Survived hospital discharge
Cawcutt et al1345
Male
New11 30033Pre-ECMO initiation (not recorded)TMP+SMX, CL, PQ13VV57Survived ITU discharge. In-hospital mortality at day 97
Steppan and
Sikazwe38
39
Male
Not recorded629769Pre-ECMO initiation (not recorded)PM+CL, then ATQ, then TMP+SMX12VV14Mortality during ECMO
De Rosa et al1221
Female
Known118 3302Pre-ECMO initiation (not recorded)TMP+SMX+FZ+MP, then CL+PQ+CF8VV20Survived hospital discharge
De Rosa et al1224
Male
New50 7283During ECMO
(8 days)
TMP+SMX10VV24Successful ECMO decannulation, but subsequent ITU in-hospital mortality
Ali et al1526
Male
New907 30284Post-ECMO
(not recorded)
TMP+SMXNot recordedVV6Survived hospital discharge
Guedes et al3965
Female
New4 050 0009Post-ECMO
(18 days)
TMP+SMX13VV10Survived hospital discharge
Horikita et al4023
Male
New550 0008.5Simultaneous to ECMO
(0 day)
TMP+SMX (additionally MP+VM+CP+MF)3VV12 initial+14 subsequent reinstitutionSurvived hospital discharge at day 62
  • ART, antiretroviral therapy; ATQ, atovaquone; CF, caspofungin; CL, clindamycin; CP, ciprofloxacin; ECMO, extracorporeal membrane oxygenation; FZ, fluconazole; ITU, intensive treatment unit; MF, micafungin; MP, meropenum; PCP, pneumocystis pneumonia; PM, pentamidine; PQ, primaquine; SMX, sulfamethoxazole; TMP, trimethoprim; VA, venoarterial; VM, vancomycin; VV, veno-venous.