Table 1

Pharmacokinetic values after administration of valganciclovir (900 mg)

Ganciclovir
Pharmacokinetic parameterSerumBrain extracellular fluid
Cmax (µmol/L)19.610.2
Tmax (h)33
T½ (h)3.24.5
Ke ß (elimination constant)0.2160.153
AUC0−12 (µmol h/L)90.061.9
AUC0−∞ (µmol h/L)90.662.5
AUC0−24 (µmol h/L)*98.676.9
Apparent clearance (mL/min)649775
  • *Calculated.