Pharmacokinetic values after administration of valganciclovir (900 mg)
| Ganciclovir | ||
|---|---|---|
| Pharmacokinetic parameter | Serum | Brain extracellular fluid |
| Cmax (µmol/L) | 19.6 | 10.2 |
| Tmax (h) | 3 | 3 |
| T½ (h) | 3.2 | 4.5 |
| Ke ß (elimination constant) | 0.216 | 0.153 |
| AUC0−12 (µmol h/L) | 90.0 | 61.9 |
| AUC0−∞ (µmol h/L) | 90.6 | 62.5 |
| AUC0−24 (µmol h/L)* | 98.6 | 76.9 |
| Apparent clearance (mL/min) | 649 | 775 |
*Calculated.