Table 1

Patients with nodular secondary syphilis reported 1992–2012

Reference	Patient (Age, gender)	Localization of skin lesions	Affection of palms or soles	Affection of mucosal membranes	Histopathology	Serology	HIV status	Treatment
Rosmaninho¹²	64, male	Neck, arms, back	No	No	Histiocytes, plasma cells	VDRL 1:512 TPHA pos	Positive	3× benzathine penicillin 2.4 M units
Jang¹¹	46, male	Scalp	No	No	Plasma cells, lymphocytes	VDRL 1:128 TPHA pos FTA pos	Negative	1× benzathine penicillin 2.4 M units
Brar, Indina J Dermatol Venereol Leprol 2007;73:437	28, male	Face, arms chest, back	No	No	Plasma cells, lymphocytes Non-sarcoidal granulomas	VDRL 1:512 TPHA pos	Negative	3× benzathine penicillin 2.4 M units
Breznik¹³	52, male	Face, upper trunk, feet	Yes (soles)	No	Plasma cells, lymphocytes, granulomas	VDRL 1:1024 TPHA 1:40960 FTA pos	Negative	3× benzathine penicillin 2.4 M units
ul Bari¹⁰	29, female	Forehad	No	No	Plasma cells	VDRL 1:512 TPHA 1:64	Negative	2× benzathine penicillin 2.4 M units
Dinotta, G Ital Dermatol Venereol 2009;144:725	29, male	Scrotum, penis	No	No	N/A	N/A	N/A	Diaminopenicillin
Battistella¹⁹	33, male	Face, arms, trunk, feet, genital region	No	No	Plasma cells, lymphocytes	VDRL 1:64 TPHA 1:10260	N/A	3× benzathine penicillin 2.4 M units
Tsai, J Am Acad Dermatol 2007;57:S57	49, male	Face, arms trunk	No	No	Plasma cells, lymphocytes, granulomas	Plasma reagin 1:128 TPHA pos	Negative	2× benzathine penicillin 2.4 M units
Pandhi, J Eur Acad Dermatol Venereol 2005;19:256	35, male	Face, arms trunk, legs	No	No	Plasma cells, giant cells	VDRL 1:128 TPHA pos	Negative	2× benzathine penicillin 2.4 M units
Engel¹⁸	34, female	Face, eyes, arms, trunk, legs	No	No	Plasma cells granulomas,	VDRL 1:512 TPHA 1:163840	Negative	Penicillin intravenous 10 M units three times a day for 4 weeks
Dave, Dermatol Online J 2003;9:9	22, male	Face, arms, trunk, legs	No	No	Granulomas	VDRL 1:64 TPHA pos	Negative	1× benzathine penicillin 2.4 M units
Harden, Arch Dermatol 1997;133:1027	39, male	Scalp, face, neck	No	No	Plasma cells	Plasma regain 1:128 TPHA pos	N/A	N/A
Papini, Br J Dermatol 1998;138:704	23, male	Trunk, arms, legs	No	No	Sarcoidal granulomas	VDRL pos TPHA 1:5120 FTA pos	Negative	3× benzathine penicillin 2.4 M units
Adriaans, Arch Dermatol 1992;128:978	40, male	Arms, legs, penis	No	No	Plasma cells, granulomas	VDRL 1:256 TPHA pos	N/A	N/A
Glatt, Clin Infect Dis 1996;23:231	29, male	Arms, feet	Yes	No	Plasma cells	VDRL 1:64 FTA pos	Positive	3× benzathine penicillin 2.4 M units, Doxycycline 100 mg twice daily for 1 month

FTA, fluorescent treponemal antibody; N/A, not available; TPHA, Treponema pallidum haemaglutination assay; VDRL, Venereal Disease Research Laboratory