PT  - JOURNAL ARTICLE
AU  - Koto, Soichi
AU  - Kanda, Yoshinobu
AU  - Ohnou, Nobuhito
AU  - Morita, Yoshinori
TI  - Chronic myeloid leukaemia with soft tissue mass formed by mature granulocytes
AID  - 10.1136/bcr-2023-258700
DP  - 2024 Jun 01
TA  - BMJ Case Reports
PG  - e258700
VI  - 17
IP  - 6
4099  - http://casereports.bmj.com/content/17/6/e258700.short
4100  - http://casereports.bmj.com/content/17/6/e258700.full
SO  - BMJ Case Reports2024 Jun 01; 17
AB  - Extramedullary lesions in patients with chronic myeloid leukaemia (CML) suggest progression to the blast phase because such lesions generally consist of immature granulocytes. We here report a case of an extramedullary mass formed by mature granulocytes during the chronic phase of CML. A 60-year-old woman who had discontinued treatment for CML with dasatinib of her own accord several years ago presented to our hospital with a complaint of right thigh pain. She had a mass on her right leg, which was located on her right thigh and was elastic, soft and fist-sized. Blood tests and the bone marrow findings were compatible with the chronic phase of CML, and a CT-guided needle biopsy showed an infiltrate containing numerous mature neutrophils and foam cells. The mass disappeared with dasatinib alone, without antibacterial agents or drainage.Although the detailed pathogenesis of mass formation with mature granulocytes in the chronic phase of CML has not been elucidated, the clinical course of the current case highlights the importance of prompt biopsy, pathological examination and the early initiation of appropriate treatment.