RT Journal Article SR Electronic T1 Marked reactive thrombocytosis in a female with iron deficiency anaemia JF BMJ Case Reports JO BMJ Case Reports FD BMJ Publishing Group Ltd SP e256738 DO 10.1136/bcr-2023-256738 VO 16 IS 11 A1 Sharma, Vishnu A1 Bagrodia, Vansh A1 Modi, Naman A1 Parchwani, Tanishk YR 2023 UL http://casereports.bmj.com/content/16/11/e256738.abstract AB This case report presents the clinical evaluation and management of a female patient from a rural background who presented with leg pain, headache, weakness and irritability. Initial investigations revealed iron deficiency anaemia accompanied by a significantly elevated platelet count, prompting suspicion of an underlying myeloproliferative neoplastic disorder. However, subsequent genetic testing ruled out these mutations, suggesting a reactive response to iron deficiency anaemia rather than an independent neoplastic process. Treatment was focused on addressing the underlying iron deficiency anaemia, resulting in significant improvement in the patient’s blood profile and resolution of symptoms. Follow-up assessments demonstrated a complete normalisation of the blood profile and platelet counts, further supporting the efficacy of the treatment. This case highlights the importance of considering reactive thrombocytosis in the context of iron deficiency anaemia and emphasises the favourable response achieved through appropriate management strategies.