PT  - JOURNAL ARTICLE
AU  - Muhammed Ali Zishan
AU  - Chin Li Tee
TI  - Adenosquamous carcinoma of the gallbladder: a rare entity and dilemmas in its management
AID  - 10.1136/bcr-2023-254883
DP  - 2023 May 01
TA  - BMJ Case Reports
PG  - e254883
VI  - 16
IP  - 5
4099  - http://casereports.bmj.com/content/16/5/e254883.short
4100  - http://casereports.bmj.com/content/16/5/e254883.full
SO  - BMJ Case Reports2023 May 01; 16
AB  - Gallbladder carcinomas are the most common form of biliary tract malignancies with adenocarcinomas, by far the most common variant while adenosquamous (adenosquamous carcinoma of the gallbladder) or pure squamous cell carcinomas representing only 2%–10% of all gallbladder carcinomas. Despite being a minority, these tumours demonstrate aggressive behaviour resulting in delayed presentations with widespread local invasion. We report a case involving a woman in her 50s who was diagnosed on imaging with a suspected gallbladder malignancy in the community. She proceeded to have a laparoscopic extended cholecystectomy with a cuff of segment 4b and 5 liver resection and cystic node sampling revealing a T3N1 lesion which on further recommendation by the multidisciplinary team proceeded to have an open portal lymphadenectomy yielding another positive lymph node. This case report highlights the dilemmas encountered in the management of this rare histological subtype in the absence of well-defined treatment algorithm and evolving guidelines.