PT  - JOURNAL ARTICLE
AU  - Tanya Marie O'Brien
TI  - Acute eosinophilic pneumonia-like syndrome post-initiation of vortioxetine
AID  - 10.1136/bcr-2022-254254
DP  - 2023 May 01
TA  - BMJ Case Reports
PG  - e254254
VI  - 16
IP  - 5
4099  - http://casereports.bmj.com/content/16/5/e254254.short
4100  - http://casereports.bmj.com/content/16/5/e254254.full
SO  - BMJ Case Reports2023 May 01; 16
AB  - A man in his mid-30s presented to the emergency department with a 1-week history of fatigue, loss of appetite, fever and productive (yellow) cough. This progressed to requiring admission to intensive care needing a oxygen therapy via high-flow nasal cannula for acute hypoxaemic respiratory failure. He had recently started vortioxetine for major depressive disorder, and his acute symptoms correlated with an increase in the dose of vortioxetine. For more than 20 years, rare but consistent reports of serotonergic medications have been implicated in eosinophilic pulmonary conditions. During this same period, serotonergic medications have become a mainstay solution for a wide range of depressive symptoms and disorders. This is the first report of an eosinophilic pneumonia-like syndrome occurring while consuming the novel serotonergic medication vortioxetine.