TY - JOUR T1 - <em>Clostridium septicum</em> brain abscess JF - BMJ Case Reports JO - BMJ Case Reports DO - 10.1136/bcr-2022-251719 VL - 15 IS - 11 SP - e251719 AU - Daryl Jian An Tan AU - Edwin Chong Yu Sng AU - Xi Wern Ling Y1 - 2022/11/01 UR - http://casereports.bmj.com/content/15/11/e251719.abstract N2 - We present a previously well woman in her 70s who was admitted for 2 weeks of progressively worsening abdominal pain, high fever and drowsiness. She was eventually diagnosed with Clostridium septicum brain abscess, meningoencephalitis and ventriculitis. The diagnosis was challenging as cerebrospinal fluid cultures were negative and a microbiological diagnosis was only obtained on brain biopsy. Despite early initiation of antibiotics that would have been effective against C. septicum, her central nervous system (CNS) infection progressed, and she eventually succumbed to the infection. Infections with C. septicum are typically fulminant and associated with high mortality. In a patient with a CNS infection and concomitant abdominal manifestations, infection with C. septicum should be considered. ER -