RT Journal Article
SR Electronic
T1 Heart failure associated with ustekinumab therapy for treatment of Crohn’s Disease
JF BMJ Case Reports
JO BMJ Case Reports
FD BMJ Publishing Group Ltd
SP e250376
DO 10.1136/bcr-2022-250376
VO 15
IS 9
A1 Morgenweck, Erica
A1 Park, Brian
A1 Bower, Richard
YR 2022
UL http://casereports.bmj.com/content/15/9/e250376.abstract
AB A man in his 60s with penetrating ileocolonic Crohn’s disease (CD), recently started on ustekinumab therapy, presented with new onset dyspnoea, paroxysmal nocturnal dyspnoea and dependent oedema. He was diagnosed with heart failure (HF) 10 months after starting ustekinumab therapy. His symptoms resolved with discontinuation of ustekinumab and he had recovery of his cardiac function. Though initial studies that led to the U.S Food and Drug Administration (FDA)approval for ustekinumab did not detect a signal for HF, postmarketing surveillance has detected rare cases of HF after initiation of the medication. This is one of the few reported cases of HF associated with ustekinumab therapy for CD.