RT Journal Article SR Electronic T1 Renal malakoplakia with invasion of the liver and diaphragm: a patient case and literature review JF BMJ Case Reports JO BMJ Case Reports FD BMJ Publishing Group Ltd SP e251254 DO 10.1136/bcr-2022-251254 VO 15 IS 9 A1 Joel Grunhut A1 Ricardo Oroz A1 Shimron Brown A1 Roozbeh Nazarian-Rostami YR 2022 UL http://casereports.bmj.com/content/15/9/e251254.abstract AB Renal malakoplakia, a seldom seen chronic inflammatory condition, continues to elude medical, surgical, radiological and pathological specialists due to its mimicry of other renal pathologies and low incidence. The variable clinical manifestations and non-specific radiological findings of malakoplakia can be misleading, and ultimately require a pathological diagnosis. A literature review reveals an extremely low prevalence of renal malakoplakia, a handful of invasive renal malakoplakia cases and no reports of liver and diaphragmatic invasion. We present a case of a renal mass with liver and diaphragmatic invasion in a 59-year-old woman that deceived clinicians and radiologists until a pathological diagnosis of renal malakoplakia was performed. This case highlights the need of awareness for malakoplakia in the differential diagnosis for renal invasive and non-invasive masses. The need to await a surgical biopsy and pathological diagnosis is critical to ensure a correct diagnosis and avoid unnecessary surgery of the kidney.