RT Journal Article SR Electronic T1 Mixed cryoglobulinaemic vasculitis with pulmonary infiltrates and cavitation JF BMJ Case Reports JO BMJ Case Reports FD BMJ Publishing Group Ltd SP e251705 DO 10.1136/bcr-2022-251705 VO 15 IS 9 A1 Adrian Mark Masnammany A1 Peter Kee Kee Wong A1 Beverly Cheok Kuan Ng A1 Nicholas Manolios YR 2022 UL http://casereports.bmj.com/content/15/9/e251705.abstract AB Cryoglobulinaemic vasculitis is an immune complex-mediated vasculitis with a myriad of clinical manifestations. We report a rare case of a patient in her 60s with rheumatoid arthritis who presented with fever of unknown origin, cutaneous leucocytoclastic vasculitis and progressive pulmonary infiltrates with cavitation. Extensive investigation for an infectious aetiology was unrevealing. Blood investigations revealed high-titre rheumatoid factor, hypocomplementaemia, raised inflammatory markers and the presence of type 2 cryoglobulins. A diagnosis of cryoglobulinaemic vasculitis with pulmonary involvement was made, and the patient was treated with high-dose prednisolone and rituximab, which resulted in complete resolution of lung changes and marked clinical improvement. This case highlights the rarity of lung involvement, including cavitation in cryoglobulinaemic vasculitis.