PT  - JOURNAL ARTICLE
AU  - Christopher R Showers
AU  - Jaslyn M Maurer
AU  - Doreen Khakshour
AU  - Mohit Shukla
TI  - Case of adult-onset Kawasaki disease and multisystem inflammatory syndrome following SARS-CoV-2 vaccination
AID  - 10.1136/bcr-2022-249094
DP  - 2022 Jul 01
TA  - BMJ Case Reports
PG  - e249094
VI  - 15
IP  - 7
4099  - http://casereports.bmj.com/content/15/7/e249094.short
4100  - http://casereports.bmj.com/content/15/7/e249094.full
SO  - BMJ Case Reports2022 Jul 01; 15
AB  - Kawasaki disease (KD) and multisystem inflammatory syndrome (MIS) are rare conditions that occur predominately in children. Recent reports document KD and MIS in adult patients following infection with SARS-CoV-2. Rarely, MIS is observed following vaccination against SARS-CoV-2, mostly in patients with prior SARS-CoV-2 infection. We report a case of KD in a man after a second SARS-CoV-2 vaccine dose, in absence of concurrent or prior SARS-CoV-2 infection. This patient also met criteria for probable MIS associated with vaccination. He tested negative for SARS-CoV-2 RNA via reverse transcriptase PCR, negative for SARS-CoV-2 nucleocapsid antibodies and demonstrated high levels SARS-CoV-2 spike protein antibodies, commonly used to assess vaccine response. Symptom improvement followed treatment with intravenous immunoglobulin, including desquamation of the hands and feet. As widespread vaccination against SARS-CoV-2 continues, increased vigilance and prompt intervention is necessary to limit the effects of postvaccination inflammatory syndromes.