PT - JOURNAL ARTICLE AU - Manon Doucet AU - Daniel Farishta AU - Jehan Abdulsattar AU - Michael Yim TI - Sphenoid sinus cholesterol granulomas presenting with abducens nerve palsy AID - 10.1136/bcr-2021-243020 DP - 2022 May 01 TA - BMJ Case Reports PG - e243020 VI - 15 IP - 5 4099 - http://casereports.bmj.com/content/15/5/e243020.short 4100 - http://casereports.bmj.com/content/15/5/e243020.full SO - BMJ Case Reports2022 May 01; 15 AB - We discuss two patients who presented with sphenoid sinus cholesterol granulomas and associated unilateral abducens nerve palsies. Two case reports from our institution are reported. A literature review of available articles is presented, discussing both cholesterol granulomas of the sphenoid sinus and sphenoid sinus lesions that present with unilateral abducens palsy. A total of nine cases of sphenoid sinus cholesterol granulomas have been previously reported in the literature. A wide variety of sphenoid sinus pathologies can present with unilateral abducens nerve palsies, however no sphenoid sinus cholesterol granulomas with this presentation were found in the literature. In conclusion, cholesterol granulomas should be included in the differential when a patient presents with an expansile mass of the sphenoid sinus and associated unilateral abducens nerve palsy.