TY - JOUR T1 - Lambert-Eaton myasthenic syndrome in a young girl JF - BMJ Case Reports JO - BMJ Case Reports DO - 10.1136/bcr-2021-245773 VL - 15 IS - 2 SP - e245773 AU - Sarah E Moor AU - Tova Gardin Y1 - 2022/02/01 UR - http://casereports.bmj.com/content/15/2/e245773.abstract N2 - Lambert-Eaton Myasthenic Syndrome (LEMS) is a neuromuscular junction defect that results in weakness. It is rarely seen in children and most commonly is associated with small-cell lung cancer. Diagnosis of LEMS requires characteristic electromyogram (EMG) findings and the detection of antibodies directed against voltage-gated calcium channels. We report the case of an 8-year-old female child who presented with profound weakness found to have EMG evidence of a neuromuscular junction defect and detectable antivoltage-gated calcium channel antibodies. She received plasma exchange electrophoresis, intravenous immunoglobulin, oral steroids and amifampridine with some clinical improvement. We present a case of a child with a demonstrated autoimmune propensity and no evidence of malignancy, thereby adding to the 12 previously reported cases of LEMS in children. ER -