RT Journal Article SR Electronic T1 Successful treatment of smouldering Human T cell Leukemia Virus Type1 associated bronchiolitis and alveolar abnormalities with amplified natural killer therapy JF BMJ Case Reports JO BMJ Case Reports FD BMJ Publishing Group Ltd SP e244619 DO 10.1136/bcr-2021-244619 VO 14 IS 12 A1 Kenjiro Nagai A1 Sho Nagai A1 Yu Hara YR 2021 UL http://casereports.bmj.com/content/14/12/e244619.abstract AB In amplified natural killer (ANK) cell immunotherapy, NK cells are extracted from the patient’s blood, cultured for enhancing its anticancer effects and amplified before they are returned to the body. Here, we administered ANK therapy to an 81-year-old female patient diagnosed with smouldering human T cell leukaemia virus-associated bronchioloalveolar disorder. After eight sessions of twice-weekly NK cell infusion, the bilateral diffuse granular shadows on a CT scan and the overall respiratory function improved markedly. Later, the patient received outpatient treatment without serious side effects. Thus, ANK therapy may be safe for elderly patients owing to its infrequent side effects.