RT Journal Article
SR Electronic
T1 Giant cell arteritis associated with PD-1 inhibition
JF BMJ Case Reports
JO BMJ Case Reports
FD BMJ Publishing Group Ltd
SP e246443
DO 10.1136/bcr-2021-246443
VO 14
IS 11
A1 Nina Couette
A1 Jisna Paul
YR 2021
UL http://casereports.bmj.com/content/14/11/e246443.abstract
AB A 50-year-old woman was referred to rheumatology for new onset polyarthralgia and headache. She had a history of metastatic lung adenocarcinoma and was started on treatment with the programmed death 1 receptor (PD-1) antagonist pembrolizumab 2 months prior. Examination revealed left temporal artery tenderness and hand synovitis. Investigations revealed enlarged temporal artery on ultrasound imaging. On steroid treatment, she had resolution of symptoms, but due to significant steroid side effects required methotrexate and her PD-1 antagonist therapy was continued in consultation with her oncologist. Her malignant disease has remained stable, and she has improved functional status.