TY - JOUR T1 - Pancreaticoduodenal artery aneurysm associated with polyarteritis nodosa presenting as massive upper gastrointestinal bleeding JF - BMJ Case Reports JO - BMJ Case Reports DO - 10.1136/bcr-2021-247359 VL - 14 IS - 11 SP - e247359 AU - Juan Carlos Reyes Abon AU - Marc Paul Jose Lopez AU - A'Ericson Berberabe AU - Kenan Jared Cinco Y1 - 2021/11/01 UR - http://casereports.bmj.com/content/14/11/e247359.abstract N2 - The pancreaticoduodenal arteries are rare sites for true aneurysm formation, but these may develop in association with occlusion of the coeliac circulation, degenerative conditions or inflammatory vascular disorders. These have a high risk of rupture regardless of size or other factors. One identified cause is polyarteritis nodosa (PAN), which is an autoimmune necrotising vascular condition that affects small-sized and medium-sized arteries. We report a case of a 40-year-old man with massive gastrointestinal tract bleeding from a ruptured pancreaticoduodenal artery aneurysm secondary to PAN. This was managed with emergent open aneurysm ligation followed by high-dose corticosteroids and cyclophosphamide pulse therapy. Only three other cases of PAN-associated pancreaticoduodenal artery aneurysms have been reported in the literature. ER -