RT Journal Article
SR Electronic
T1 Large and rapid local recurrence of clear cell renal cell carcinoma
JF BMJ Case Reports
JO BMJ Case Reports
FD BMJ Publishing Group Ltd
SP e247106
DO 10.1136/bcr-2021-247106
VO 14
IS 11
A1 Thomson, Alice
A1 Hennessey, Derek
A1 Goad, Jeremy
A1 Kinnear, Ned
YR 2021
UL http://casereports.bmj.com/content/14/11/e247106.abstract
AB After radical nephrectomy, clear cell renal cell carcinoma (ccRCC) recurs locally in <3% of patients. Recurrences typically occur 1-2 years postoperatively and grow at 5–20 mm per year. In contrast, this patient’s recurrence was unexpectedly large and swift. A 71-year-old woman was initially found on workup for recurrent urinary tract infections to have a 12 cm left renal tumour. After negative staging scans, she progressed to left open radical nephrectomy. Histology revealed a stage T2b 12 cm ccRCCwith sarcomatoid differentiation, International Society of Urological Pathology (ISUP) grade 4, with clear margins. Only 3 months later, the patient developed left-sided abdominal pain, and CT scans revealed a 15 cm left retroperitoneal local recurrence, as well as widespread peritoneal tumours. In discussion with her treating team, the patient and her family elected not to undergo biopsy or systemic therapy. The patient was palliated and passed away 8 days after re-presentation.