RT Journal Article SR Electronic T1 Isolated proximal weakness of the legs due to neuroborreliosis JF BMJ Case Reports JO BMJ Case Reports FD BMJ Publishing Group Ltd SP e244431 DO 10.1136/bcr-2021-244431 VO 14 IS 11 A1 Simone Nibourg A1 Martijn Beudel A1 Jeroen Trip YR 2021 UL http://casereports.bmj.com/content/14/11/e244431.abstract AB Proximal muscle weakness of the legs is a symptom with a broad differential diagnosis. It is mainly caused by neuromuscular disorders and is often a diagnostic challenge. Here, we present a 73-year-old man with isolated proximal weakness of the legs due to lumbar root involvement on the basis of neuroborreliosis. After treatment with intravenous antibiotics he recovered completely. This is the first described case with isolated proximal muscle weakness of the legs due to neuroborreliosis. Despite the fact neuroborreliosis is a rare cause of proximal muscle weakness of the legs, clinicians should include it in their differential diagnosis, especially since it is a treatable condition.