TY - JOUR T1 - Improvement of hyperadrenergic postural orthostatic tachycardia syndrome (POTS) with methylated B vitamins in the setting of a heterozygous COMT Val158Met polymorphism JF - BMJ Case Reports JO - BMJ Case Reports DO - 10.1136/bcr-2021-245012 VL - 14 IS - 11 SP - e245012 AU - Nikita Mittal AU - Ariel Portera AU - Pam Taub Y1 - 2021/11/01 UR - http://casereports.bmj.com/content/14/11/e245012.abstract N2 - A middle-aged woman was diagnosed with postural orthostatic tachycardia syndrome based on her clinical symptoms, elevated norepinephrine levels and positive tilt-table test. The patient was refractory to conventional treatment and improved only after she was treated with methylated B vitamins for her heterozygous catechol-O-methyltransferase Val158Met polymorphism. ER -