%0 Journal Article %A Lauré M Fijen %A Aldo Grefhorst %A Johannes H M Levels %A Danny M Cohn %T Severe acquired hypertriglyceridemia following COVID-19 %D 2021 %R 10.1136/bcr-2021-246698 %J BMJ Case Reports %P e246698 %V 14 %N 11 %X Severe hypertriglyceridemia is a major risk factor for acute pancreatitis. In exceptional cases, it is caused by plasma components inhibiting lipoprotein lipase activity. This phenomenon is predominantly associated with autoimmune diseases. Here, we report a case of severe hypertriglyceridemia due to a transient reduction in lipoprotein lipase activity following an episode of COVID-19 in an otherwise healthy 45-year-old woman. The lipoprotein lipase activity of the patient was markedly reduced compared with a healthy control and did recover to 20% of the healthy control’s lipoprotein lipase activity 5 months after the COVID-19 episode. Mixing tests substantiated reduced lipolytic capacity in the presence of the patient’s plasma at presentation compared with a homozygous lipoprotein lipase-deficient control, which was no longer present at follow-up. Western blotting confirmed that the quantity of lipoprotein lipase was not aberrant. Fibrate treatment and a strict hypolipidemic diet improved the patient’s symptoms and triglyceride levels. %U https://casereports.bmj.com/content/bmjcr/14/11/e246698.full.pdf