PT  - JOURNAL ARTICLE
AU  - Muhammad Amin ur Rahman
AU  - Khalid Al Wadi
AU  - Al Nuqaydan
AU  - Raghad Tallab
TI  - Primary ovarian synovial sarcoma
AID  - 10.1136/bcr-2021-244756
DP  - 2021 Nov 01
TA  - BMJ Case Reports
PG  - e244756
VI  - 14
IP  - 11
4099  - http://casereports.bmj.com/content/14/11/e244756.short
4100  - http://casereports.bmj.com/content/14/11/e244756.full
SO  - BMJ Case Reports2021 Nov 01; 14
AB  - Synovial sarcoma (SS) has a rare occurrence in the female genital tract. Only three prior reports of primary ovarian sarcoma could be retrieved after a thorough literature review. We are reporting a case of primary ovarian SS in a young woman. The tumour showed monophasic spindle cell morphology, and there was a wide list of differential diagnosis to consider. We confirmed the diagnosis by cytogenetics Flourescent Insitu Hybridisation (FISH) technique to identify the classical translocation. The diagnosis of this disease can be challenging especially if the tumour is of monophasic type. Morphology and immunohistochemistry are not enough to confirm the diagnosis in many cases. A confirmatory molecular pathology test is paramount. We have discussed the differential diagnosis of spindle cell tumours in ovary. We suggest that SS should be in the differential diagnoses when facing any atypical spindle cell tumour in the ovary. Molecular pathology techniques can help to confirm the diagnosis.