PT  - JOURNAL ARTICLE
AU  - Julia R Schiff
AU  - Benjamin P Fiorillo
AU  - Raha Sadjadi
AU  - Tracey L Henry
AU  - Judah K Gruen
AU  - Lauren M Gensler
TI  - Confabulation, amnesia and motor memory loss as a presentation of apparent ITPR1 antibody autoimmune encephalitis
AID  - 10.1136/bcr-2021-244316
DP  - 2021 Sep 01
TA  - BMJ Case Reports
PG  - e244316
VI  - 14
IP  - 9
4099  - http://casereports.bmj.com/content/14/9/e244316.short
4100  - http://casereports.bmj.com/content/14/9/e244316.full
SO  - BMJ Case Reports2021 Sep 01; 14
AB  - A 59-year-old woman presented to the hospital with acute, hypoactive altered mental status. Her symptoms had begun 3 days prior when she developed hallucinations, urinary and faecal incontinence, and somnolence. She also exhibited confabulations, amnesia, motor memory loss and a wide-based gait. Medical, psychiatric and neurological evaluations including imaging and laboratory workup were unrevealing. Treatment for possible Wernicke encephalopathy and psychosis with high-dose intravenous thiamine and antipsychotic medications did not lead to improvement. After discharge, a send-out cerebrospinal fluid autoimmune encephalitis panel resulted positive for the newly identified neuronal inositol triphosphate receptor one (ITPR1) antibody. This prompted readmission for intravenous steroids, plasmapheresis and intravenous immunoglobulin, which yielded mild clinical improvement. Here, we describe confabulations and psychiatric symptoms as novel manifestations of the primary presentation of anti-ITPR1 encephalitis in an effort to promote faster recognition of this disease and early initiation of treatment in suspected cases.