RT Journal Article SR Electronic T1 Rare complication of ceftriaxone therapy: drug-induced thrombocytopenia (DITP) JF BMJ Case Reports JO BMJ Case Reports FD BMJ Publishing Group Ltd SP e245228 DO 10.1136/bcr-2021-245228 VO 14 IS 9 A1 Aishwarya Sharma A1 Devendranath Mannuru A1 Abhishek Matta A1 Amit Kaushal YR 2021 UL http://casereports.bmj.com/content/14/9/e245228.abstract AB A 62-year-old woman with a history of end-stage renal disease on haemodialysis, essential hypertension and type 2 diabetes mellitus was diagnosed with sepsis and placed on 600 mg oral linezolid every 12 hours and 1 g intravenous ceftriaxone every 24 hours. Blood cultures grew Streptococcus dysgalactiae, and she was switched to intravenous ceftriaxone 2 g daily. Platelet counts slowly trended down after starting ceftriaxone reaching 5 K/μL on day 12 of treatment. Ceftriaxone was discontinued and heparin-induced thrombocytopaenia was ruled out. She was switched to vancomycin and her platelet count improved. Given the temporal relationship between changing platelet counts and starting and discontinuing ceftriaxone, a diagnosis of drug-induced thrombocytopaenia was made.