PT  - JOURNAL ARTICLE
AU  - Aishwarya Sharma
AU  - Devendranath Mannuru
AU  - Abhishek Matta
AU  - Amit Kaushal
TI  - Rare complication of ceftriaxone therapy: drug-induced thrombocytopenia (DITP)
AID  - 10.1136/bcr-2021-245228
DP  - 2021 Sep 01
TA  - BMJ Case Reports
PG  - e245228
VI  - 14
IP  - 9
4099  - http://casereports.bmj.com/content/14/9/e245228.short
4100  - http://casereports.bmj.com/content/14/9/e245228.full
SO  - BMJ Case Reports2021 Sep 01; 14
AB  - A 62-year-old woman with a history of end-stage renal disease on haemodialysis, essential hypertension and type 2 diabetes mellitus was diagnosed with sepsis and placed on 600 mg oral linezolid every 12 hours and 1 g intravenous ceftriaxone every 24 hours. Blood cultures grew Streptococcus dysgalactiae, and she was switched to intravenous ceftriaxone 2 g daily. Platelet counts slowly trended down after starting ceftriaxone reaching 5 K/μL on day 12 of treatment. Ceftriaxone was discontinued and heparin-induced thrombocytopaenia was ruled out. She was switched to vancomycin and her platelet count improved. Given the temporal relationship between changing platelet counts and starting and discontinuing ceftriaxone, a diagnosis of drug-induced thrombocytopaenia was made.