TY - JOUR T1 - Central nervous system metastases: a rare presentation of nasopharyngeal carcinoma JF - BMJ Case Reports JO - BMJ Case Reports DO - 10.1136/bcr-2021-243892 VL - 14 IS - 8 SP - e243892 AU - Sehrish Abrar AU - Nasir Ali AU - Bilal Mazhar Qureshi AU - Rabia Tahseen Y1 - 2021/08/01 UR - http://casereports.bmj.com/content/14/8/e243892.abstract N2 - We report a case of a male patient. He presented with nasal obstruction and epistaxis. The MRI of the brain showed a mass in the nasopharynx and enlarged cervical lymph nodes. Besides this, there was an extra-axial, dural-based lesion in brain and subcentimetre nodules in both lungs. He received induction chemotherapy followed by chemoradiation therapy to the primary site and dural-based metastatic deposit. He re-presented with bilateral lower limb weakness. The MRI of the spine showed metastatic deposits within the thoracic cord parenchyma and meningeal deposits at the lumbar region. Palliative radiation was used to treat spinal cord and meningeal metastases. He died a few months later because of systemic disease progression. Considering the rarity of this presentation in nasopharyngeal carcinoma and lack of clear guidelines for standard treatment, we report this case to share our experience of management. ER -