TY - JOUR T1 - Immune thrombocytopenic purpura and acute liver injury after COVID-19 vaccine JF - BMJ Case Reports JO - BMJ Case Reports DO - 10.1136/bcr-2021-242678 VL - 14 IS - 7 SP - e242678 AU - Adam Hines AU - Janice Gloria Shen AU - Coral Olazagasti AU - Shakil Shams Y1 - 2021/07/01 UR - http://casereports.bmj.com/content/14/7/e242678.abstract N2 - A 26-year-old woman was sent to the emergency room by her primary care physician for a new petechial rash and thrombocytopenia 2 weeks after receiving the Moderna mRNA-1273 SARS-CoV-2 vaccine. Her hospital course was complicated by transaminitis. Her platelet count improved to normal on hospital day 5 after receiving intravenous steroids and intravenous immunoglobulin to treat her suspected diagnosis of immune thrombocytopenic purpura. Extensive workup for her thrombocytopenia and transaminitis was unremarkable including ruling out infectious, autoimmune and toxic causes. A liver biopsy was unrevealing and her transaminitis was improved on discharge. Although not proven, the temporal relationship of her vaccination with thrombocytopenia and abnormal liver enzymes points towards the Moderna mRNA-1273 SARS-CoV-2 vaccine as the most likely inciting factor. ER -