TY - JOUR T1 - COVID-19-related vasculopathy of the brain JF - BMJ Case Reports JO - BMJ Case Reports DO - 10.1136/bcr-2021-242028 VL - 14 IS - 7 SP - e242028 AU - Hui Wen Liang AU - Sai Man Mung AU - Chris Douglass AU - Edward B Jude Y1 - 2021/07/01 UR - http://casereports.bmj.com/content/14/7/e242028.abstract N2 - The COVID-19 pandemic is revealing growing reports of atypical presentation of the disease beyond the respiratory system. SARS-CoV-2 infection has been linked to multisystem vasculopathy including cardiopulmonary, cerebral and renal vasculature, potentially brought on by a dysregulated host immune response in a probable setting of a cytokine storm. Here, we describe a case of a previously healthy and active 74-year-old man presenting with acute cognitive decline with preceding non-specific influenza-like symptoms. He was then diagnosed with cerebral amyloid angiopathy (CAA)-associated intracerebral haemorrhage and was found to be COVID-19 positive. COVID-19-induced immune response may have further compromised the cerebral vessels already weakened by CAA, triggering multiple microhaemorrhages leading to clinical presentation. The limited evidence about the heterogeneity of COVID-19 manifestations suggests that clinicians should be aware and screen for concurrent COVID-19 in patients presenting with neurological features during the peak of this pandemic, as this offers the best chance for better clinical outcome. ER -