PT  - JOURNAL ARTICLE
AU  - Navneet Kaur
AU  - Anand Kumthekar
AU  - Bibi Ayesha
TI  - When sarcoidosis mimics immunodeficiency
AID  - 10.1136/bcr-2021-243557
DP  - 2021 Jul 01
TA  - BMJ Case Reports
PG  - e243557
VI  - 14
IP  - 7
4099  - http://casereports.bmj.com/content/14/7/e243557.short
4100  - http://casereports.bmj.com/content/14/7/e243557.full
SO  - BMJ Case Reports2021 Jul 01; 14
AB  - Sarcoidosis is a granulomatous disease with a wide spectrum of clinical manifestations. A 28-year-old previously healthy woman presented with multifocal pneumonia, mediastinal lymphadenopathy which was thought to be caused by actinomyces infection. Despite antibiotics, she developed cavitary lung lesions and had worsening lymphadenopathy prompting evaluation for alternative aetiologies like malignancy, autoimmune or immunodeficiency disorders. Further workup also revealed low CD4, CD8 cell counts, elevated soluble interleukin-2 levels. Over the due course of time, she developed granulomatous pan-uveitis, classical skin lesions leading to the diagnosis of sarcoidosis. Our case highlights the rare manifestations of sarcoidosis which can mimic immunodeficiency disorders especially when these patients develop secondary infections. Our goal is to raise awareness among clinicians about these atypical presentations of sarcoidosis which can lead to substantial delay in diagnosis thus leading to progression of the disease in the absence of appropriate treatment.