PT - JOURNAL ARTICLE AU - Josephine B de Leoz AU - Devi Suravajjala AU - Hashmi Rafeek AU - Vani Selvan TI - Primary mammary actinomycosis challenged with penicillin allergy AID - 10.1136/bcr-2020-235883 DP - 2021 Jul 01 TA - BMJ Case Reports PG - e235883 VI - 14 IP - 7 4099 - http://casereports.bmj.com/content/14/7/e235883.short 4100 - http://casereports.bmj.com/content/14/7/e235883.full SO - BMJ Case Reports2021 Jul 01; 14 AB - Actinomycosis is a subacute-to-chronic bacterial infection caused by gram-positive, filamentous, non-acid-fast, facultative anaerobic bacteria. It is a normal commensal bacterium found in the oral cavity and the lower reproductive tract of women. We present a case of primary actinomycosis of the breast. A postmenopausal woman, complicated by penicillin allergy, presented with a left breast lump clinically simulating malignancy. The first line of treatment for actinomycosis is penicillin. Due to a penicillin allergy, the patient was initially treated with doxycycline. However, doxycycline was discontinued due to tremors, and was replaced by clindamycin. The patient had a good clinical response with resolution of the abscess.