PT  - JOURNAL ARTICLE
AU  - Azad, Shorya Vardhan
AU  - Banerjee, Mousumi
AU  - Parmanand, Kumar
AU  - Venkatesh, Pradeep
TI  - Isolated optic nerve involvement in acute lymphoblastic leukaemia: a red flag for early relapse
AID  - 10.1136/bcr-2021-243689
DP  - 2021 Jun 01
TA  - BMJ Case Reports
PG  - e243689
VI  - 14
IP  - 6
4099  - http://casereports.bmj.com/content/14/6/e243689.short
4100  - http://casereports.bmj.com/content/14/6/e243689.full
SO  - BMJ Case Reports2021 Jun 01; 14
AB  - Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer, with 70%–80% of cases curable with modern chemotherapy. However, 20% of the cases suffer from disease relapse with bone marrow being the most common site. Isolated ocular involvement as the first sign of relapse is extremely rare, occurring in less than 2.2% of cases. The presentation of optic nerve involvement in leukaemia represents a visual emergency and a sign of isolated central nervous system relapse even in the absence of abnormal cerebrospinal fluid cytology. This case highlights the importance of routine ophthalmic screening in ALL even during maintenance phase and prompt initiation of treatment in cases with isolated optic nerve involvement.