PT - JOURNAL ARTICLE AU - Caitlyn N Myrdal AU - Delaney B Stratton AU - Tracy L Davis AU - Clara Curiel-Lewandrowski TI - Generalised eruptive histiocytosis preceded by systemic symptoms AID - 10.1136/bcr-2021-243411 DP - 2021 Jun 01 TA - BMJ Case Reports PG - e243411 VI - 14 IP - 6 4099 - http://casereports.bmj.com/content/14/6/e243411.short 4100 - http://casereports.bmj.com/content/14/6/e243411.full SO - BMJ Case Reports2021 Jun 01; 14 AB - Generalised eruptive histiocytosis is a rare proliferative disease that typically presents with indolent cutaneous eruptions. We describe the case of a 73-year-old man presenting with diffuse, asymptomatic crops of pink to dusky red papules preceded by general malaise, myalgias, fluctuating fever, chills, and weight loss. Histological evaluation revealed a non-Langerhans cell histiocytic dermal infiltrate with spindle cell features and chronic inflammation, reactive for CD68 and negative for both S100 and CD1a. Malignancy screening was negative. This report aims to highlight a unique presentation of generalised eruptive histiocytosis, emphasise histological findings, and discuss considerations for malignancy screening.