RT Journal Article SR Electronic T1 Fatal donor-derived Kaposi sarcoma following liver transplantation JF BMJ Case Reports JO BMJ Case Reports FD BMJ Publishing Group Ltd SP e236061 DO 10.1136/bcr-2020-236061 VO 14 IS 6 A1 Matthew Moore McCrea Copeland A1 James Trainor A1 W Johnny Cash A1 Conor Braniff YR 2021 UL http://casereports.bmj.com/content/14/6/e236061.abstract AB Human herpesvirus-8 (HHV8) is a recognised precursor for a number of neoplastic and non-neoplastic processes. Immunosuppressed recipients of both solid organ and haematopoietic stem cell transplants are at risk of life-threatening lytic reactivations of HHV8-infected B-lymphocytes, primary infections after receiving grafts from HHV8-seropositive donors and more rarely by the direct transplantation of malignant Kaposi sarcoma cells seeded within graft tissue. We describe the case of an HHV8-seronegative patient with confirmed, post-orthotopic liver transplant transmission of HHV8 from a seropositive donor with quantitative evidence of viraemia and subsequent development of disseminated visceral and cutaneous Kaposi sarcoma with a rapidly fatal outcome.