TY - JOUR T1 - Fatal donor-derived Kaposi sarcoma following liver transplantation JF - BMJ Case Reports JO - BMJ Case Reports DO - 10.1136/bcr-2020-236061 VL - 14 IS - 6 SP - e236061 AU - Matthew Moore McCrea Copeland AU - James Trainor AU - W Johnny Cash AU - Conor Braniff Y1 - 2021/06/01 UR - http://casereports.bmj.com/content/14/6/e236061.abstract N2 - Human herpesvirus-8 (HHV8) is a recognised precursor for a number of neoplastic and non-neoplastic processes. Immunosuppressed recipients of both solid organ and haematopoietic stem cell transplants are at risk of life-threatening lytic reactivations of HHV8-infected B-lymphocytes, primary infections after receiving grafts from HHV8-seropositive donors and more rarely by the direct transplantation of malignant Kaposi sarcoma cells seeded within graft tissue. We describe the case of an HHV8-seronegative patient with confirmed, post-orthotopic liver transplant transmission of HHV8 from a seropositive donor with quantitative evidence of viraemia and subsequent development of disseminated visceral and cutaneous Kaposi sarcoma with a rapidly fatal outcome. ER -