PT  - JOURNAL ARTICLE
AU  - Matthew Moore McCrea Copeland
AU  - James Trainor
AU  - W Johnny Cash
AU  - Conor Braniff
TI  - Fatal donor-derived Kaposi sarcoma following liver transplantation
AID  - 10.1136/bcr-2020-236061
DP  - 2021 Jun 01
TA  - BMJ Case Reports
PG  - e236061
VI  - 14
IP  - 6
4099  - http://casereports.bmj.com/content/14/6/e236061.short
4100  - http://casereports.bmj.com/content/14/6/e236061.full
SO  - BMJ Case Reports2021 Jun 01; 14
AB  - Human herpesvirus-8 (HHV8) is a recognised precursor for a number of neoplastic and non-neoplastic processes. Immunosuppressed recipients of both solid organ and haematopoietic stem cell transplants are at risk of life-threatening lytic reactivations of HHV8-infected B-lymphocytes, primary infections after receiving grafts from HHV8-seropositive donors and more rarely by the direct transplantation of malignant Kaposi sarcoma cells seeded within graft tissue. We describe the case of an HHV8-seronegative patient with confirmed, post-orthotopic liver transplant transmission of HHV8 from a seropositive donor with quantitative evidence of viraemia and subsequent development of disseminated visceral and cutaneous Kaposi sarcoma with a rapidly fatal outcome.